Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

Aging is associated with central fat redistribution and insulin resistance. To identify age-related adipose features, we evaluated the senescence and adipogenic potential of adipose-derived stromal cells (ASCs) from abdominal subcutaneous fat obtained from healthy normal-weight young (<25 yea...

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Bibliographic Details
Main Authors: Laura Le Pelletier, Matthieu Mantecon, Jennifer Gorwood, Martine Auclair, Roberta Foresti, Roberto Motterlini, Mireille Laforge, Michael Atlan, Bruno Fève, Jacqueline Capeau, Claire Lagathu, Veronique Bereziat
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
senescence
adipose stromal cells
adipogenesis
oxidative stress
metformin
AMPK
Online Access:https://elifesciences.org/articles/62635

Internet

https://elifesciences.org/articles/62635

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