Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter

Isoindolinones as Michael Donors under Phase Transfer Catalysis: Enantioselective Synthesis of Phthalimidines Containing a Tetrasubstituted Carbon Stereocenter

Readily available chiral ammonium salts derived from cinchona alkaloids have proven to be effective phase transfer catalysts in the asymmetric Michael reaction of 3-substituted isoindolinones. This protocol provides a convenient method for the construction of valuable asymmetric 3,3-disubstituted i...

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Bibliographic Details
Main Authors: Francesco Scorzelli, Antonia Di Mola, Laura Palombi, Antonio Massa
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
synthetic methods
asymmetric catalysis
nitrogen heterocycles
conjugate addition
chiral phase transfer catalysts
Online Access:http://www.mdpi.com/1420-3049/20/5/8484

Internet

http://www.mdpi.com/1420-3049/20/5/8484

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