DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients

DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from RA patients (RA-FLS). An in vitro study using MH...

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Bibliographic Details
Main Authors: Mini Jeong, Jong-Il Shin, Jaewook Cho, Yong-Joon Jeon, Jin-Hyun Kim, Jeehee Youn, Kyungho Lee
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
CHOP
DHA
ER stress
RA-FLSs
ROS
Online Access:https://www.mdpi.com/1422-0067/24/2/1734

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https://www.mdpi.com/1422-0067/24/2/1734

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