Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells

Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells

Summary: Calcineurin (CN) inhibitors currently used to avoid transplant rejection block the activation of adaptive immune responses but also prevent the development of tolerance toward the graft, by directly inhibiting T cells. CN, through the transcription factors of the NFAT family, plays an impor...

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Bibliographic Details
Main Authors: Miriam Colombo, Laura Marongiu, Francesca Mingozzi, Roberta Marzi, Clara Cigni, Fabio Alessandro Facchini, Rany Rotem, Mihai Valache, Giulia Stucchi, Giuseppe Rocca, Laura Gornati, Maria Antonietta Rizzuto, Lucia Salvioni, Ivan Zanoni, Alessandro Gori, Davide Prosperi, Francesca Granucci
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Health sciences
Drugs
Immunology
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013141

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222013141

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