The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease

Abstract Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Althou...

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Bibliographic Details
Main Authors: Alexander A. Sosunov, Guy M. McKhann, James E. Goldman
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Acta Neuropathologica Communications
Subjects:
Rosenthal fibers
Alexander disease
Astrocytes
GFAP
alphaB-crystallin
Online Access:http://link.springer.com/article/10.1186/s40478-017-0425-9

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http://link.springer.com/article/10.1186/s40478-017-0425-9

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