Re-directing CD4+ T cell responses with the flanking residues of MHC class II-bound peptides: the core is not enough
Recombinant αβ T cell receptors (TCRs) recognise short peptides presented at the cell surface in complex with MHC molecules. There are two main subsets of αβ T cells: CD8+ T cells that recognise mainly cytosol-derived peptides in the context of MHC class I (pMHC-I), and CD4+ T cells that recognise p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00172/full |