Mitochondrial metabolism sustains CD8+ T cell migration for an efficient infiltration into solid tumors

Mitochondrial metabolism sustains CD8+ T cell migration for an efficient infiltration into solid tumors

Abstract The ability of CD8+ T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T cell migration in tumors is critical, so that strategies to intervene on these targets can b...

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Bibliographic Details
Main Authors: Luca Simula, Mattia Fumagalli, Lene Vimeux, Irena Rajnpreht, Philippe Icard, Gary Birsen, Dongjie An, Frédéric Pendino, Adrien Rouault, Nadège Bercovici, Diane Damotte, Audrey Lupo-Mansuet, Marco Alifano, Marie-Clotilde Alves-Guerra, Emmanuel Donnadieu
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46377-7

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https://doi.org/10.1038/s41467-024-46377-7

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