Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity

Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity

Abstract Background Cancers exhibit complex transcriptomes with aberrant splicing that induces isoform-level differential expression compared to non-diseased tissues. Transcriptomic profiling using short-read sequencing has utility in providing a cost-effective approach for evaluating isoform expres...

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Bibliographic Details
Main Authors: Saranga Wijeratne, Maria E. Hernandez Gonzalez, Kelli Roach, Katherine E. Miller, Kathleen M. Schieffer, James R. Fitch, Jeffrey Leonard, Peter White, Benjamin J. Kelly, Catherine E. Cottrell, Elaine R. Mardis, Richard K. Wilson, Anthony R. Miller
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Genomics
Subjects:
Long-read RNA sequencing
Concatenation
Isoform discovery
Tumor transcriptome
Online Access:https://doi.org/10.1186/s12864-024-10021-x

Internet

https://doi.org/10.1186/s12864-024-10021-x

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