Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m<sup>2</sup>) and age-/sex-matched nonobese (18.5 kg/m<sup>2</sup> ≥ BMI ≤ 30 kg/m<sup&g...

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Bibliographic Details
Main Authors: Philipp Simon, David Petroff, David Busse, Jana Heyne, Felix Girrbach, Arne Dietrich, Alexander Kratzer, Markus Zeitlinger, Charlotte Kloft, Frieder Kees, Hermann Wrigge, Christoph Dorn
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antibiotics
Subjects:
antibiotic dosing
concentrations
meropenem
microdialysis
obesity
pharmacokinetics
Online Access:https://www.mdpi.com/2079-6382/9/12/931

Internet

https://www.mdpi.com/2079-6382/9/12/931

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