Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry

Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry

Aiming to elucidate the system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (interactome) in human liver microsomes (HLM) with chemical crosslinking mass spectrometry (CXMS)....

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Bibliographic Details
Main Authors: Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak S. Ahire, Bhagwat Prasad, Victor G. Zgoda
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
chemical crosslinking mass spectrometry (CXMS)
alcohol exposure
alcohol-drug interactions
drug metabolism
protein-protein interactions
cytochrome P450
Online Access:https://www.mdpi.com/2218-273X/12/2/185

Internet

https://www.mdpi.com/2218-273X/12/2/185

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