Ablation of Calsequestrin-1, Ca2+ unbalance, and susceptibility to heat stroke

Ablation of Calsequestrin-1, Ca2+ unbalance, and susceptibility to heat stroke

Introduction: Ca2+ levels in adult skeletal muscle fibers are mainly controlled by excitation-contraction (EC) coupling, a mechanism that translates action potentials in release of Ca2+ from the sarcoplasmic reticulum (SR) release channels, i.e. the ryanodine receptors type-1 (RyR1). Calsequestrin (...

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Bibliographic Details
Main Authors: Feliciano Protasi, Barbara Girolami, Matteo Serano, Laura Pietrangelo, Cecilia Paolini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Physiology
Subjects:
Ca2+ entry unit (CEU)
calsequestrin (Casq)
excitation-contraction (EC) coupling
store-operated Ca2+ entry (SOCE)
malignant hyperthermia susceptibility (MHS)
ryanodine receptor (RyR)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1033300/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.1033300/full

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