Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues

Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues

Ethyl 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylate ((±)-1) was resolved with O,O'-dibenzoyltartaric acid via diastereomeric salt formation. The efficient synthesis of the enantiomers of 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid ((+)-7 and (–)-7), 3-endo-aminobicyclo...

Full description

Bibliographic Details
Main Authors: Márta Palkó, Mikko M. Hänninen, Reijo Sillanpää, Ferenc Fülöp
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
bicyclic β-amino acid derivatives
constrained chiral β-amino acids
resolution
continuous flow hydrogenations
Online Access:http://www.mdpi.com/1420-3049/18/12/15080

Internet

http://www.mdpi.com/1420-3049/18/12/15080

Similar Items