Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-β2

Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-β2

Abstract Background Gastrointestinal stromal tumors (GISTs) are the prevailing sarcomas of the gastrointestinal tract. Tyrosine kinase inhibitors (TKIs) therapy, exemplified by Imatinib mesylate (IM), constitutes the established adjuvant therapy for GISTs. Nevertheless, post-treatment resistance pos...

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Bibliographic Details
Main Authors: Yu Zhao, Zuyi Weng, Xuan Zhou, Zhi Xu, Bei Cao, Bin Wang, Juan Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Mesenchymal stromal cells
Tumor microenvironment
Gastrointestinal stromal tumors
TGF-β
PI3K-AKT
Imatinib mesylate
Online Access:https://doi.org/10.1186/s12967-023-04063-0

Internet

https://doi.org/10.1186/s12967-023-04063-0

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