Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

Purpose: Mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic pressure. However, long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and astrocytes. Given that neural stem cell (NSC) is a subpo...

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Bibliographic Details
Main Authors: Hai-Zhen Duan, Xin Zhou, Quan Hu, Meng-Long Liu, Shu-Hong Wang, Ji Zhang, Xu-Heng Jiang, Tian-Xi Zhang, An-Yong Yu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Chinese Journal of Traumatology
Subjects:
Mannitol
Cerebral edema
Neural stem cell
Proliferation
AQP4
p38 MAPK signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1008127523001025

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http://www.sciencedirect.com/science/article/pii/S1008127523001025

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