Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework

Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework

Summary: Background: There is a lack of consensus on the optimal serum valproic acid (VPA) concentration for maintenance therapy in bipolar disorder (BD). We aimed to investigate the association between serum VPA levels and risk of mood episode recurrence. Methods: We enrolled patients with BD from...

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Bibliographic Details
Main Authors: Yang-Chieh Brian Chen, Chih-Sung Liang, Liang-Jen Wang, Kuo-Chuan Hung, Andre F. Carvalho, Marco Solmi, Eduard Vieta, Ping-Tao Tseng, Pao-Yen Lin, Yu-Kang Tu, Chih-Wei Hsu, Edward Chia-Cheng Lai
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EClinicalMedicine
Subjects:
Bipolar disorder
Effectiveness
Prophylaxis
Serum level
Valproate
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537022004084

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http://www.sciencedirect.com/science/article/pii/S2589537022004084

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