Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring

Summary: Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, the precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced FGR mouse models, we observe learning and memory deficits in adult FGR offsprin...

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Bibliographic Details
Main Authors: Wen Chen, Nana Liu, Shijun Shen, Wei Zhu, Jing Qiao, Shujuan Chang, Jianfeng Dong, Mingliang Bai, Li Ma, Shanshan Wang, Wenwen Jia, Xudong Guo, Ang Li, Jiajie Xi, Cizhong Jiang, Jiuhong Kang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
fetal growth restriction
cognition
hippocampal neurogenesis
neural stem cells
Tet1
Notch signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013851

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http://www.sciencedirect.com/science/article/pii/S2211124721013851

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