Prospective Use of High-Refractive Index Materials for Single Molecule Detection in Flow Cytometry

Prospective Use of High-Refractive Index Materials for Single Molecule Detection in Flow Cytometry

Phenotyping extracellular vesicles (EVs), where surface receptor expression is often as low as one molecule per EV, remains problematic due to the inability of commercial flow cytometers to provide single-fluorescent molecule sensitivity. While EVs are widely considered to be of great potential as d...

Full description

Bibliographic Details
Main Authors: Joshua A. Welsh, Julia Kepley, Ariel Rosner, Peter Horak, Jay A. Berzofsky, Jennifer C. Jones
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Sensors
Subjects:
extracellular vesicles
flow cytometry
light scatter
scatter modelling
complex refractive index
scatter labels
NanoTags
single-epitope detection
Online Access:http://www.mdpi.com/1424-8220/18/8/2461

Internet

http://www.mdpi.com/1424-8220/18/8/2461

Similar Items