Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium

Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium

Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences their biomechanical properties which are crucial for the cell...

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Bibliographic Details
Main Authors: Felix Reichel, Martin Kräter, Kevin Peikert, Hannes Glaß, Philipp Rosendahl, Maik Herbig, Alejandro Rivera Prieto, Alexander Kihm, Giel Bosman, Lars Kaestner, Andreas Hermann, Jochen Guck
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Physiology
Subjects:
chorea-acanthocytosis
blood cell deformability
real-time deformability cytometry
dasatinib
lithium
cell mechanics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.852946/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.852946/full

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