Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Abstract Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such as Citrus microcarpa, Ruta graveolen...

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Bibliographic Details
Main Authors: Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim, Joong-Hoon Ahn
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Microbial Cell Factories
Subjects:
Acridone
Metabolic engineering
Polyketide synthase
Online Access:http://link.springer.com/article/10.1186/s12934-020-01331-2

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http://link.springer.com/article/10.1186/s12934-020-01331-2

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