Hypoxia-induced mitochondrial DNA release promotes proliferation of pulmonary arterial smooth muscle cells via activating cGAS-STING pathway

Objective To investigate the role and possible mechanism of mitochondrial DNA (mtDNA) release in the proliferation of rat pulmonary arterial smooth muscle cells (RPASMCs) induced by hypoxia. Methods ① RPASMCs were divided into normoxia group, hypoxia 24-hour group and hypoxia 48-hour group (n=3 for...

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Bibliographic Details
Main Authors: WEI Hannan, CHEN Dewei, ZHANG Erlong, GAO Yuqi
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2022-01-01
Series:Di-san junyi daxue xuebao
Subjects:
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202107134.htm