Waking immune-resistant tumors with neddylation
The CD47/signal regulatory protein α (SIRPα) axis, which functions as an inhibitory phagocytosis checkpoint, also serves as a key mediator in cancer immune evasion. Many cancers, including colorectal cancer (CRC), exploit the expression of CD47 to escape phagocytic clearance and activate the innate...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2023-02-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI167894 |