Polygenic risk associated with Alzheimer’s disease and other traits influences genes involved in T cell signaling and activation

IntroductionT cells, known for their ability to respond to an enormous variety of pathogens and other insults, are increasingly recognized as important mediators of pathology in neurodegeneration and other diseases. T cell gene expression phenotypes can be regulated by disease-associated genetic var...

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Bibliographic Details
Main Authors: Dallin Dressman, Shinya Tasaki, Lei Yu, Julie Schneider, David A. Bennett, Wassim Elyaman, Badri Vardarajan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337831/full