Optimization of the Heterologous Expression of the Cannabinoid Type-1 (CB1) Receptor

Optimization of the Heterologous Expression of the Cannabinoid Type-1 (CB1) Receptor

The G protein-coupled type 1 cannabinoid receptor (CB1R) mediates virtually all classic cannabinoid effects, and both its agonists and antagonists hold major therapeutic potential. Heterologous expression of receptors is vital for pharmacological research, however, overexpression of these proteins m...

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Bibliographic Details
Main Authors: Viktória B. Horváth, Eszter Soltész-Katona, Éva Wisniewski, Anikó Rajki, Eszter Halász, Balázs Enyedi, László Hunyady, András Dávid Tóth, Gergő Szanda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Endocrinology
Subjects:
CB1 receptor
receptor degradation
cannabinoids
weak promoters
heterologous expression
non-canonical signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.740913/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.740913/full

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