Combined Targeting of Pathogenetic Mechanisms in Pancreatic Neuroendocrine Tumors Elicits Synergistic Antitumor Effects

Combined Targeting of Pathogenetic Mechanisms in Pancreatic Neuroendocrine Tumors Elicits Synergistic Antitumor Effects

Pancreatic neuroendocrine neoplasms (PanNENs) are the second most common malignancy of the pancreas. Surgery remains the only curative treatment for localized disease. For patients with inoperable advanced or metastatic disease, few targeted therapies are available, but their efficacy is unpredictab...

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Bibliographic Details
Main Authors: Sebastian Gulde, Alessia Foscarini, Simon L. April-Monn, Edoardo Genio, Alessandro Marangelo, Swapna Satam, Daniel Helbling, Massimo Falconi, Rodrigo A. Toledo, Jörg Schrader, Aurel Perren, Ilaria Marinoni, Natalia S. Pellegata
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
pancreatic NETs
buparlisib
ribociclib
combination therapy
primary human tumoroids
Online Access:https://www.mdpi.com/2072-6694/14/22/5481

Internet

https://www.mdpi.com/2072-6694/14/22/5481

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