Recovery of strain-resolved genomes from human microbiome through an integration framework of single-cell genomics and metagenomics

Abstract Background Obtaining high-quality (HQ) reference genomes from microbial communities is crucial for understanding the phylogeny and function of uncultured microbes in complex microbial ecosystems. Despite improvements in bioinformatic approaches to generate curated metagenome-assembled genom...

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Bibliographic Details
Main Authors: Koji Arikawa, Keigo Ide, Masato Kogawa, Tatsuya Saeki, Takuya Yoda, Taruho Endoh, Ayumi Matsuhashi, Haruko Takeyama, Masahito Hosokawa
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Microbiome
Subjects:
Online Access:https://doi.org/10.1186/s40168-021-01152-4