Label-free superior contrast with c-band ultra-violet extinction microscopy
Abstract In 1934, Frits Zernike demonstrated that it is possible to exploit the sample’s refractive index to obtain superior contrast images of biological cells. The refractive index contrast of a cell surrounded by media yields a change in the phase and intensity of the transmitted light wave. This...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-03-01
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| Series: | Light: Science & Applications |
| Online Access: | https://doi.org/10.1038/s41377-023-01105-6 |