Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS

Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron degeneration in the central nervous system. Recent research has increasingly linked the activation of nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome to ALS pathogene...

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Bibliographic Details
Main Authors: Hilal Cihankaya, Verian Bader, Konstanze F. Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschke
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Cells
Subjects:
amyotrophic lateral sclerosis
motor neuron degeneration
NLRP3 inflammasome
miR-223-3p
pyroptotic cell death
wobbler mouse
Online Access:https://www.mdpi.com/2073-4409/13/12/995

Internet

https://www.mdpi.com/2073-4409/13/12/995

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