Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins

<p>Abstract</p> <p>Background</p> <p>Sunitinib malate (SUTENT<sup>®</sup>) is an oral, multitargeted tyrosine kinase inhibitor, approved multinationally for the treatment of advanced RCC and of imatinib-resistant or – intolerant GIST. The purpose of this stu...

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Bibliographic Details
Main Authors: Spinella Dominic, Baum Charles M, Smeraglia John, Bello Carlo L, DePrimo Samuel E, Rini Brian I, Michaelson M Dror, Motzer Robert J
Format: Article
Language:English
Published: BMC 2007-07-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/5/1/32