Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

Improvement of Resveratrol Permeation through Sublingual Mucosa: Chemical Permeation Enhancers versus Spray Drying Technique to Obtain Fast-Disintegrating Sublingual Mini-Tablets

Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of a...

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Bibliographic Details
Main Authors: Giulia Di Prima, Giuseppe Angellotti, Amalia Giulia Scarpaci, Denise Murgia, Fabio D’agostino, Giuseppina Campisi, Viviana De Caro
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
resveratrol
sublingual mucosa
spray drying
chemical permeation enhancers
menthol
lysine
Online Access:https://www.mdpi.com/1999-4923/13/9/1370

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https://www.mdpi.com/1999-4923/13/9/1370

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