DTDHM: detection of tandem duplications based on hybrid methods using next-generation sequencing data

DTDHM: detection of tandem duplications based on hybrid methods using next-generation sequencing data

Background Tandem duplication (TD) is a common and important type of structural variation in the human genome. TDs have been shown to play an essential role in many diseases, including cancer. However, it is difficult to accurately detect TDs due to the uneven distribution of reads and the inherent...

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Bibliographic Details
Main Authors: Tianting Yuan, Jinxin Dong, Baoxian Jia, Hua Jiang, Zuyao Zhao, Mengjiao Zhou
Format: Article
Language:English
Published: PeerJ Inc. 2024-07-01
Series:PeerJ
Subjects:
Tandem duplications
Structural variations
Hybrid methods
K-nearest neighbor algorithm
Next-generation sequencing
Short-read sequence
Online Access:https://peerj.com/articles/17748.pdf

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https://peerj.com/articles/17748.pdf

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