Decoupling the correlation between cytotoxic and exhausted T lymphocyte states enhances melanoma immunotherapy response prediction

Decoupling the correlation between cytotoxic and exhausted T lymphocyte states enhances melanoma immunotherapy response prediction

Summary: Cytotoxic T lymphocyte (CTL) and terminal exhausted T lymphocyte (ETL) activities crucially influence immune checkpoint inhibitor (ICI) response. Despite this, the efficacy of ETL and CTL transcriptomic signatures for response prediction remains limited. Investigating this across the TCGA a...

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Bibliographic Details
Main Authors: Binbin Wang, Kun Wang, Di Wu, Sahil Sahni, Peng Jiang, Eytan Ruppin
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:iScience
Subjects:
Biological sciences
Immunology
Biocomputational method
Computational bioinformatics
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224011489

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http://www.sciencedirect.com/science/article/pii/S2589004224011489

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