Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. Addressing the therapeutic potential of modulating...

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Bibliographic Details
Main Authors: Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2742736?pdf=render

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http://europepmc.org/articles/PMC2742736?pdf=render

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