Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Co-delivery of different species of protein-encoding polynucleotides, e.g., messenger RNA (mRNA) and plasmid DNA (pDNA), using the same nanocarrier is an interesting topic that remains scarcely researched in the field of nucleic acid delivery. The current study hence aims to explore the possibility...

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Bibliographic Details
Main Authors: Sarah S. Nasr, Sangeun Lee, Durairaj Thiyagarajan, Annette Boese, Brigitta Loretz, Claus-Michael Lehr
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
nucleic acid vaccine
complex coacervation
nanocarriers
anisotropic nanogel
physical cross-linking
dual loading
Online Access:https://www.mdpi.com/1999-4923/13/11/1924

Internet

https://www.mdpi.com/1999-4923/13/11/1924

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