Single-cell data-driven mathematical model reveals possible molecular mechanisms of embryonic stem-cell differentiation

Single-cell data-driven mathematical model reveals possible molecular mechanisms of embryonic stem-cell differentiation

Embryonic development is widely studied due to its application in disease treatment. The published literature demonstrated that Krüppel-like factor 8(KLF8) plays an important role in modulating mesendoderm to definitive endoderm (DE) differentiation. However, it is not clear how KLF8 interacts with...

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Bibliographic Details
Main Authors: Xiao Tu, Qinran Zhang, Wei Zhang, Xiufen Zou
Format: Article
Language:English
Published: AIMS Press 2019-06-01
Series:Mathematical Biosciences and Engineering
Subjects:
embryonic stem cells(escs)
single-cell data
bifurcation
molecular mechanisms
tristability
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2019294?viewType=HTML

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https://www.aimspress.com/article/doi/10.3934/mbe.2019294?viewType=HTML

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