Transcriptome Analysis of Monocytes and Fibroblasts Provides Insights Into the Molecular Features of Periodontal Ehlers-Danlos Syndrome

Transcriptome Analysis of Monocytes and Fibroblasts Provides Insights Into the Molecular Features of Periodontal Ehlers-Danlos Syndrome

Periodontal Ehlers–Danlos syndrome (pEDS) is a rare hereditary disorder characterized by severe early-onset periodontitis with premature tooth loss, pretibial hyperpigmentation, and skin fragility. It is caused by mutant variants in the C1R and C1S genes that result in C4 cleavage and local compleme...

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Bibliographic Details
Main Authors: Zhuoyi Liao, Tian Zhao, Ningxiang Wang, Jiaqi Chen, Weibin Sun, Juan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Genetics
Subjects:
Ehlers-Danlos syndrome
periodontitis
transcriptomics
monocytes
RNA-sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.834928/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.834928/full

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