NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing

NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound Healing

Abstract Heterotopic ossification (HO) represents an unwanted ossific wound healing response to the soft tissue injury which caused catastrophic limb dysfunction. Recent studies established the involvement of inflammation and cellular senescence in the tissue healing process, though their role in HO...

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Bibliographic Details
Main Authors: Juehong Li, Xin Wang, Zhixiao Yao, Feng Yuan, Hang Liu, Zhenyu Sun, Zhengqiang Yuan, Gang Luo, Xiangyun Yao, Haomin Cui, Bing Tu, Ziyang Sun, Cunyi Fan
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
cellular senescence
extracellular vesicles
heterotopic ossification
macrophages
pyroptosis
Online Access:https://doi.org/10.1002/advs.202207383

Internet

https://doi.org/10.1002/advs.202207383

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