Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers

Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers

Antipsychotics are associated with severe metabolic side effects including insulin resistance; however, the mechanisms underlying this side effect are not fully understood. The skeletal muscle plays a critical role in insulin-stimulated glucose uptake, and changes in skeletal muscle DNA methylation...

Full description

Bibliographic Details
Main Authors: Kyle J. Burghardt, Paul R. Burghardt, Bradley H. Howlett, Sabrina E. Dass, Brent Zahn, Ahmad A. Imam, Abdullah Mallisho, Zaher Msallaty, Berhane Seyoum, Zhengping Yi
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Biomedicines
Subjects:
epigenetic
antipsychotic
muscle
Online Access:https://www.mdpi.com/2227-9059/12/5/1057

Internet

https://www.mdpi.com/2227-9059/12/5/1057

Similar Items