Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells

Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells

Despite great potential for regenerative medicine, the high tumorigenic potential of human pluripotent stem cells (hPSCs) to form undesirable teratoma is an important technical hurdle preventing safe cell therapy. Various small molecules that induce the complete elimination of undifferentiated hPSCs...

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Bibliographic Details
Main Authors: Young-Hyun Go, Changjin Lim, Ho-Chang Jeong, Ok-Seon Kwon, Sungkyun Chung, Haeseung Lee, Wankyu Kim, Young-Ger Suh, Woo Sung Son, Mi-Ok Lee, Hyuk-Jin Cha, Seok-Ho Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Chemistry
Subjects:
stemotoxics
naphthoquinone imidazolium
SAR (structure-activity relationship)
human pluripotent stem cells
teratoma
YM155
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00298/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00298/full

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