Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression

Abstract Phosphorylation proteomics is the basis for the study of abnormally activated kinase signaling pathways in breast cancer, which facilitates the discovery of new oncogenic agents and drives the discovery of potential targets for early diagnosis and therapy of breast cancer. In this study, we...

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Bibliographic Details
Main Authors: Yujiao Deng, Zhanwu Hou, Yizhen Li, Ming Yi, Ying Wu, Yi Zheng, Fei Yang, Guansheng Zhong, Qian Hao, Zhen Zhai, Meng Wang, Xiaobin Ma, Huafeng Kang, Fanpu Ji, Chenfang Dong, Huadong Liu, Zhijun Dai
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Phosphoproteomic
Kinase activity
PRKCD
Src
Online Access:https://doi.org/10.1186/s12964-024-01487-z

Internet

https://doi.org/10.1186/s12964-024-01487-z

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