Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2

Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, uses a surface expressed trimeric spike glycoprotein for cell entry. This trimer is the primary target for neutralizing antibodies making it a key candidate for vaccine development. During t...

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Bibliographic Details
Main Authors: Eduardo M. Bruch, Shaolong Zhu, Lisa Szymkowicz, Taylor Blake, Tara Kiss, D. Andrew James, Alexey Rak, Kartik Narayan, Matthew T. Balmer, Roman M. Chicz
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-52499-1

Internet

https://doi.org/10.1038/s41598-024-52499-1

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