Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of “off-the-shelf” CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strategy to cont...

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Bibliographic Details
Main Authors: Anne-Sophie Gautron, Alexandre Juillerat, Valérie Guyot, Jean-Marie Filhol, Emilie Dessez, Aymeric Duclert, Philippe Duchateau, Laurent Poirot
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
multiplex gene editing
genotoxicity
TALEN
immunotherapy
chimeric antigen receptors
checkpoint inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302664

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http://www.sciencedirect.com/science/article/pii/S2162253117302664

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