A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.

A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.

BACKGROUND: Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transporter. Endogenous DA modulates glutamatergic inputs to striatal neurons and this modulation influences motor activity. Since D2 DA and A2A-adenosine receptors (A2A-Rs) have antagonistic effec...

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Bibliographic Details
Main Authors: Alessandro Tozzi, Antonio de Iure, Valentina Marsili, Rosaria Romano, Michela Tantucci, Massimiliano Di Filippo, Cinzia Costa, Francesco Napolitano, Nicola Biagio Mercuri, Franco Borsini, Carmen Giampà, Francesca Romana Fusco, Barbara Picconi, Alessandro Usiello, Paolo Calabresi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3371006?pdf=render

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http://europepmc.org/articles/PMC3371006?pdf=render

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