Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis

Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis

Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments are urgently needed considering that lung transplantation is the only treatment that could improve outcomes. This study aimed to investigate the therapeutic signifi...

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Bibliographic Details
Main Authors: Dalia H. El-Kashef, Mahmoud E. Youssef, Mohamed Nasr, Mohammed Alrouji, Sharif Alhajlah, Othman AlOmeir, Noura El Adle Khalaf, Dalia M. Abdel Ghaffar, Lubna Jamil, Zeinab M. Abdel-Nasser, Samar Ibrahim, Mahmoud Said Ibrahim Abdeldaiem, Sally S. Donia, Osama A. Mohammed, Nesreen Elsayed Morsy, Ahmed Shata, Sameh Saber
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Bleomycin
Nifuroxazide
Pimitespib
STAT3
HIF-1α
IL-6/STAT3/HIF-1α autocrine loop
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222008769

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http://www.sciencedirect.com/science/article/pii/S0753332222008769

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