Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis.

Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis.

Lipolysis in adipocytes is regulated by phosphorylation of lipid droplet-associated proteins, including perilipin 1A and hormone-sensitive lipase (HSL). Perilipin 1A is potentially phosphorylated by cAMP(adenosine 3',5'-cyclic monophosphate)-dependent protein kinase (PKA) on several sites,...

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Bibliographic Details
Main Authors: Patrick M McDonough, Dominique Maciejewski-Lenoir, Sean M Hartig, Rita A Hanna, Ross Whittaker, Andrew Heisel, James B Nicoll, Benjamin M Buehrer, Kurt Christensen, Maureen G Mancini, Michael A Mancini, Dean P Edwards, Jeffrey H Price
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566132?pdf=render

Internet

http://europepmc.org/articles/PMC3566132?pdf=render

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