Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

IntroductionSARS coronavirus 2 (SARS-CoV-2) infects human angiotensin-converting enzyme 2 (hACE2)-expressing lung epithelial cells through its spike (S) protein. The S protein is highly glycosylated and could be a target for lectins. Surfactant protein A (SP-A) is a collagen-containing C-type lectin...

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Bibliographic Details
Main Authors: Ikechukwu B. Jacob, Amanda Gemmiti, Weichuan Xiong, Erin Reynolds, Brian Nicholas, Saravanan Thangamani, Hongpeng Jia, Guirong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
biomarker
COVID-19
innate immunity
SARS-CoV-2
spike protein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1370511/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1370511/full

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