Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition

Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses produced by analgesic drugs. However, the relevant epoxygenase(s) remain unidentified. Presently, we describe the tissue distribution, high-throug...

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Bibliographic Details
Main Authors: Jun Yang, Melissa A. VanAlstine, James G. Phillips, Mark P. Wentland, Lindsay B. Hough
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000196