Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe

Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe

Hepatitis C virus (HCV) NS3/4A protease is an attractive target for direct-acting antiviral agents. Real-time tracking of the NS3/4A protease distribution and activity is useful for clinical diagnosis and disease management. However, no approach has been developed that can systemically detect NS3/4A...

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Bibliographic Details
Main Authors: Chih-Hung Chuang, Tian-Lu Cheng, Wei-Chun Chen, Yi-Jung Huang, Hsin-Ell Wang, Yen-Chen Lo, Yuan-Chin Hsieh, Wen-Wei Lin, Ya-Ju Hsieh, Chien-Chih Ke, Kang-Chieh Huang, Jin-Ching Lee, Ming-Yii Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
cellular protease activity
HCV NS3/4A serine protease
protease-activated retention peptide
micro-positron emission tomography
TAT-ΔNS3/4A-124I-FITC probe
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.896588/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.896588/full

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