TGF-β signaling: critical nexus of fibrogenesis and cancer

TGF-β signaling: critical nexus of fibrogenesis and cancer

Abstract The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. It functions through canonical SMAD-mediated processes and noncanonical pathways involving MAPK cascades, PI3K/AKT, Rho-...

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Bibliographic Details
Main Authors: Anna O. Giarratana, Conor M. Prendergast, Mary M. Salvatore, Kathleen M. Capaccione
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Translational Medicine
Subjects:
TGF-β
Cell signaling
Fibrosis
Cancer
Theranostics
Precision medicine
Online Access:https://doi.org/10.1186/s12967-024-05411-4

Internet

https://doi.org/10.1186/s12967-024-05411-4

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