Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice

Alzheimer’s disease (AD) is the most common neurodegenerative disorder affecting 5.4 million people in the United States. Currently approved pharmacologic interventions for AD are limited to symptomatic improvement, not affecting the underlying pathology. Therefore, the search for novel th...

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Bibliographic Details
Main Authors: Quoc-Viet Duong, Margia L. Kintzing, William E. Kintzing, Ihab M. Abdallah, Andrew D. Brannen, Amal Kaddoumi
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
blood-brain barrier
amyloid-β clearance
brain endothelial cells
vascular endothelial growth factor
plasma rich growth factors
Online Access:https://www.mdpi.com/1422-0067/20/6/1489

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https://www.mdpi.com/1422-0067/20/6/1489

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