Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Abstract Background Precision therapeutics continuously make advances in cancer therapy, and a field of growing interest is the combination of targeted radionuclide therapy (TRNT) with potential radiosensitizing agents. This study evaluated whether the effects of in vitro TRNT, using the 177Lu-label...

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Bibliographic Details
Main Authors: Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:EJNMMI Research
Subjects:
PM2
TRNT
Radiosensitization
pErk1/2 induction
3D tumor models
Online Access:http://link.springer.com/article/10.1186/s13550-020-0613-7

Internet

http://link.springer.com/article/10.1186/s13550-020-0613-7

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